Buccleuch Place is a two-and-a-half-storey vernacular residence with mixed Greek Revival and Neo-classical elements at the end of Shirreff Street in Rothesay.

The building's original owner was John Shirreff, whom Shirreff Street is named after. Shirreff was a merchant and businessman whose specialty was selling processed fish abroad. He was also High Sheriff to Northumberland County for twenty-six years, a position held onto right up until his death in 1897. Also of note is his daughter Jenny. Jenny was a benefactor who is notable for donating Shirreff Hall, the women’s residence, to Dalhousie University in 1920. Supposedly, it was the single largest gift to a Canadian university up to that date. Jenny's husband was Ezra Butler Eddy, founder of the E. B. Eddy Company, a manufacturer of matches and other wood products. Eddy was also a politician who once acted as mayor of Hull, Quebec.

Following Shirreff's death, the residence was acquired by J. D. B. F. MacKenzie. MacKenzie was a druggist who had operated his own business, 'MacKenzie’s Medical Hall’, since 1892. MacKenzie was involved in the local community in several ways, being the co-founder and first president of the New Brunswick Pharmaceutical Society, a director of Dalhousie University, and a member of the Miramichi Natural History Museum. MacKenzie also had a notable military career, being Lieutenant Colonel and commanding officer of Miramichi 73rd Militia Battalion and serving as aide-de-camp to Lieutenant Governor J.B. Snowball. During the First World War, MacKenzie led the taking of Newcastle’s Wireless Field in defending Canada from enemy forces.