The Dr. George Frederick Clarke House is notable for being a rare example of an Edwardian residence in New Brunswick, as well as its association with original owner Charles Gardner and later occupant Dr. George Frederick Clarke.

As stated above, the Dr. George Frederick Clarke House is one of the few examples of Edwardian architecture in Woodstock and in New Brunswick as a whole. It features a hipped roof and rusticated sandstone ornamentation on the north, east, and south elevations. Originally, the front façade was completely symmetrical except for a now-removed oval window left of the door. A garage extension has been added to the left side of the house in recent years as well. Some other notable features include the balanced placement of chimneys on either end of the roof, six columns that support the shed-roofed veranda, the "spinning wheel" decorative element above the centre of the veranda, and the beautiful Palladian dormer in the middle of the front façade's roof.

Originally, the house was built for Charles Gardner and his wife, Alice Connell, daughter of the Honourable Charles Connell. Gardner was a surveyor and engineer whose claim to fame was surveying the right of way through Crow’s Nest Pass on the Alberta-British Columbia border in the Rockies, leading to the house being nicknamed the Crow’s Nest. However, Gardner ultimately decided not to live in the house.

In 1913, the residence was sold to Dr. George Frederick Clarke, a local man known for his many talents. Clarke was a historian, author, anthropologist, sport fisherman, conservationist, and amateur dentist. Clarke published several works relating to the Acadian and aboriginal histories of New Brunswick, as well as pieces advocating for increased protections for New Brunswick's river systems. He continued to live in this house until his death in 1974, and afterwards the building remained in the Clarke family.