Since its construction in 1910, the Léger Pharmacie has served an important role for Shediac's Acadian community. Initially, the building was occupied by Acadia Drugs (la pharmacie acadienne), run by brothers Raymond and Georges Léger. Georges Léger is notable for being the first Acadian to graduate from the Collège des Pharmaciens du Nouveau-Brunswick, having earned his diploma in 1909. The pharmacy was later acquired by Joseph Goguen, who operated it from 1962 until the 1980s. As of 1984, the building has hosted a number of different businesses.

The Léger Pharmacy was the first pharmacy in Shediac to be owned by a Francophone and provide services in French. Outside of Moncton, it was the only pharmacy of its kind in southeastern New Brunswick.

The Léger Pharmacy also serves as a good if modest example of a trading house-style commercial building from the 20th century, with its ornamental brickwork and twin parapets. The design of the building was crafted by noted Moncton architect René Fréchet.