The Renzetta Residence is a one-and-a-half-story building topped by a gable roof, with a gable-end wall facing the street. While most of the exterior has been modified over the years, there are enough original attributes to reflect the typical late 19th-century structure. For example, almost all of the fenestration is original, aside from the double windows in the gables that were originally single windows.
 
The exact year of construction is uncertain, but the building is known to have been built in the second half of the 19th century. For a period of time, it hosted Edward Carney's shop, then it was sold to Robert Phinney in 1894. Phinney moved the building to its current location at 21 Court Street and opened a shoemaker's shop that would operate until c. 1920. The new location was important as it was right next to the McMinn tannery. Opening in the early 1850s, the tannery was first owned by David McMinn and was inherited by his son, Robert McMinn.
 
Around 1930, the store was modified to serve as a residence for Emma Fitzpatrick, whose father James Fitzpatrick had purchased the McMinn property in 1918, and her husband Frank Renzetta. "Renzetta", originally named Frank Kohler and also known by his other stage name "Rhenzetter", was a multi- talented entertainer, performing comedy, ventriloquy, juggling, and other acts. Emma was not only Frank's wife but his co-star as well. Under the names "Renzetta & Emma" and "The Renzetta", the duo found success in New York City, acting at, among other places, New York’s Hippodrome Theatre and Palace Theatre under the employment of the Keith Circuit of Theatres. Their most famous work was perhaps playing Vaudeville versions of "Maggie and Jiggs", the lead characters from the popular cartoon strip "Bringing Up Father" by George McManus, which focused on a newly-wealthy Irish immigrant and his overbearing wife. The show took place in 1914 and was produced by famed Vaudeville performer Gus Hill. The Renzetta Residence served as the couple's home while staying in Emma's native Richibucto. Emma died in 1950 at the age of 73, while Frank Renzetta died in 1955 at the age of 77.