The Wallace Twins Houses are a pair of Sussex residences known for their former owners and Queen Anne Revival-style architecture.
 
The residences were originally owned by twin brothers George and Fenwick Wallace, having been erected by their father George H. Wallace in 1875. The twins both worked as carpenters before later entering the undertaking industry. In 1893, Fenwick Wallace founded the Wallace Funeral Home, which would remain in the Wallace family before being sold to Steve Baldwin in 1994. He would then go on to help found the New Brunswick Funeral Directors Association in 1907 and create the Canadian Funeral Directors Magazine. Outside of undertaking, Fenwick also served as mayor of Sussex in 1915 and 1916.
 
The house at 376 Main Street was later occupied by Harold Russell Bryant, MD. Dr. Bryant also purchased the next-door property, which became his medical office. He had a fifty-year-long career in medicine. Byrant was also regularly involved in various public matters, such as helping organize projects such as the Anglican Church Homes and the Kiwanis Nursing Home and serving the town's mayor from 1965 to 1966.
 
Architecture-wise, the Wallace Twins Houses bear similar Queen Anne Revival-style designs and mainly diverge in terms of their entrances; while 380 Main Street has a small gable-roofed porch, 376 Main Street has a rounded roof over its fanlight. For both buildings, a skirt is built over the second storey set of windows with shingle siding on the gable end, while the rest of the front façade features clapboard siding. The buildings' windows, still present for the original construction, bear a postcard-style etched design on the upper sash glass.